Kalyn's Kitchen

Pepperoni Pizza Chicken Bake (Video)

Try this Pepperoni Pizza Chicken Bake when you need some delicious low-carb comfort food that the whole family is going to love!

PIN Pepperoni Pizza Chicken Bake to make it later!

Pepperoni Pizza Chicken Bake finished pizza bake in baking dish

This Pepperoni Pizza Chicken Bake is for everyone who’s been carefully watching what they eat during January and is now craving something that qualifies as comfort food. And although nothing might be quite as comforting as real pepperoni pizza, this chicken with pizza flavors is completely delicious and definitely scratches that pizza itch with something that’s also very low in carbs. 

I made this a couple of times with my nephew Jake to get it just right. The first time we didn’t reduce the pizza sauce and the sauce was too watery. We also tried it first with turkey pepperoni, which was fine if that’s what you prefer, but this recipe doesn’t take a lot of pepperoni and the full-fat pepperoni definitely crisped up a lot better.

But every time we tested this we happily gobbled it up, so use the type of pepperoni you prefer for this popular recipe that I’m featuring for Friday Favorites this week; I hope you’ll put this on your menu soon! And if you’re really craving pizza, check out The BEST Low-Carb and Gluten-Free Recipes with Pizza Flavors for more low-carb and Keto recipes for pizza or pizza-flavored dishes!

What Ingredients do you need for this recipe?

  • low-sugar pizza sauce (See note below about pizza sauce)
  • large boneless-skinless chicken breasts (at least 8 oz. each)
  • olive oil
  • Greek oregano (sometimes just called oregano)
  • garlic powder
  • Mozzarella cheese, sliced 
  • sliced pepperoni (regular or turkey pepperoni)

What Pizza Sauce Should You Use for Low-Carb?

I’ve been pleasantly surprised to find a couple of brands of pizza sauce that are pretty low in carbs, but I use Rao’s Pizza Sauce (affiliate link) which has only 3 carbs in 1/4 cup.

Low-Carb Pepperoni Pizza Chicken Bake process shots collage

How to Make Low-Carb Pepperoni Pizza Chicken Bake:

(Scroll down for complete printable recipe with nutritional information.)

  1.  Don’t skip the step of simmering the sauce on low until it’s reduced to one cup.
  2. Trim chicken well, cut each breast in half, and then pound until they’re as thin as you can get with out the chicken shredding apart. (I use a meat mallet (affiliate link) but anything heavy will work.
  3. Season chicken with oregano-garlic powder mix, and then quickly brown the chicken on both sides.  (It won’t be cooked through.)
  4. Layer the chicken pieces in a glass casserole dish that’s barely big enough to fit the chicken. 
  5. Spread each piece with a generous amount of the reduced sauce. 
  6. Put a thin slice of Mozzarella and few slices of pepperoni on each chicken breast. 
  7. Bake at 400F/200C for 25-30 minutes, or until the cheese is melted and starting to slightly brown.
  8. Serve hot and wait for compliments.
  9. If you’re reheating leftovers, I recommend you cover the dish to keep the chicken from drying out.

Pepperoni Pizza Chicken Bake square image of finished pizza bake in baking dish

More Low-Carb Ideas with Pizza Flavors:

Low-Carb Deconstructed Pizza Casserole ~ Kalyn’s Kitchen
Pepperoni Pizza Cauliflower Casserole ~ I Breathe I’m Hungry
Julia Child’s Eggplant Pizzas ~ Kalyn’s Kitchen
Flourless, Gluten-Free Low-Carb Pizza ~ Gluten-Free Easily
Zucchini Crust Pizza Margherita ~ Kalyn’s Kitchen

Weekend Food Prep:

This recipe has been added to a category called Weekend Food Prep  to help you find recipes you can prep or cook on the weekend and eat during the week!

Pepperoni Pizza Chicken Bake finished pizza bake in baking dish

Pepperoni Pizza Chicken Bake

Yield Makes 8 servings.
Prep Time 25 minutes
Cook Time 30 minutes
Total Time 55 minutes

Try this low-carb Pepperoni Pizza Chicken Bake when you need some low-carb and gluten-free comfort food!


  • 1 jar (14 oz) low-sugar pizza sauce, reduced to 1 cup (See note about pizza sauce)
  • 4 very large boneless-skinless chicken breasts (at least 8 oz. each)
  • 1 T olive oil
  • 1 tsp. Greek oregano (sometimes just called oregano)
  • 1 tsp. garlic powder
  • 6 oz. piece of Mozzarella, sliced about 1/4 inch thick
  • 2 oz. sliced pepperoni (regular or turkey pepperoni)


  1. Preheat oven to 400F/200C. 
  2. Put the pizza sauce in a small saucepan and simmer over low heat until it's reduced to one cup, about 20 minutes.  Don't skip this step or the dish will be watery.
  3. While the sauce reduces, trim the chicken breasts and cut each one crosswise to make two same-size pieces.  Put chicken pieces one at a time inside a heavy plastic bag and use a meat mallet (affiliate link) (or something heavy) to pound the chicken until it's as thin as you can get it without it shredding apart.  (Don't worry if some pieces break apart a little.) 
  4. Mix the Greek Oregano (affiliate link) and garlic powder in a little bowl and then sprinkle both sides of each piece of chicken with the mixture.
  5. Heat the olive oil over medium-high heat in the largest non-stick frying pan you have (you may have to do this in 2 batches if your pan isn't big enough.) Add the chicken pieces and cook 1-2 minutes on each side, just long enough to brown the chicken but not long enough to cook it through.
  6. Choose the smallest glass casserole dish you have that will fit all the browned chicken pieces, and lay the chicken in the dish in a single layer.  Cut the Mozzarella into slices and cut the slices as needed to make enough pieces to mostly cover the top of each piece of chicken.
  7. By now the sauce should be nicely reduced, so spread sauce over the top of each chicken breast.  (Use it all.)  Top each piece with sliced Mozzarella and pepperoni slices, covering the top of each piece of chicken as much as you can.
  8. Bake uncovered about 25-30 minutes, or until the cheese is melted and starting to brown and the pepperoni is slightly crisped.  (Some pieces of pepperoni will slice off the chicken, try not to obsess about that like I did.)  Serve hot.
  9. This was great reheated in the microwave for a few minutes, although you might not have any left!


Use the lowest-carb pizza sauce you can find or make your own pizza sauce to keep the carbs low for this recipe.

Recipe created by Kalyn.

Nutrition Information:



Serving Size:


Amount Per Serving: Calories: 221Total Fat: 12gSaturated Fat: 5gUnsaturated Fat: 6gCholesterol: 75mgSodium: 317mgCarbohydrates: 4gFiber: 0gSugar: 1gProtein: 25g

Nutrition information is automatically calculated by the Recipe Plug-In I am using. I am not a nutritionist and cannot guarantee 100% accuracy, since many variables affect those calculations. (I'm not sure why the carb count is coming out quite so low on this recipe.)

If you make this recipe I'd love to hear how it turns out. Leave a star rating or share on social media with the hashtag #KALYNSKITCHEN, thanks!


Low-Carb Diet / Low-Glycemic Diet / South Beach Diet Suggestions:
This Pepperoni Pizza Chicken Bake with full-fat cheese and pepperoni should be great for traditional low-carb and Keto eating plans if you’re careful to choose low-carb pizza sauce (or make your own). You could use skim-milk Mozzarella and turkey pepperoni for the South Beach Diet. We definitely liked it best with full-fat pepperoni, but quite a bit of the fat is left in the dish.

Find More Recipes Like This One:
Use Casserole Recipes to find more recipes like this one. Use the Diet Type photo index pages to find more recipes suitable for a specific eating plan. You might also like to Follow Kalyn’s Kitchen on Pinterest to see all the good recipes I’m sharing there.

Pinterest image of Low-Carb Pepperoni Pizza Chicken Bake

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    193 Comments on “Pepperoni Pizza Chicken Bake (Video)”

  1. As a mom of 3 boy athletes I have to find ways to fill them up and keep their energy high! This would also be good to put between 2 slices of toasted garlic bread for an on the go meal for them while I keep it low carb for me!! Can’t wait to try this!

  2. Looks good and easy to make. It’s like making pizza but the crust is chicken which is healthier and waaay better! We’ll try it this weekend Thank you so much for the recipe.

  3. This is a brilliant idea! I love pizza but I’m doing keto and I thought I’d never be able to eat pizza again! You changed my life! You can buy the thin chicken in the grocery store!  Thank you so much for this pizza idea!

    • So glad you like it. Some stores don’t have those thin chicken cutlets, but if your store carries them that’s a great option!

  4. Made this tonight and it was excellent! I didn’t spend the time reducing the Rao’s more than half, so it wasn’t as thick, but what a great entree. It’s the kind of thing that’s good enough to eat as intended for someone watching carbs, but with some extra sauce and cooked spaghetti it would be a great dinner that would include those not watching carbs. It just tasted that good. Thanks for a great chicken recipe!

    • Oh good, so glad you enjoyed it! And I am always happy when people can figure out how to make my recipes work for a family-friendly dinner!

  5. This is delicious! It was easy to prepare. At first, I didn’t like all the different pans, but it’s worth it

  6. This is the first recipe I have seen from you.  I made it tonight for hubby, daughter and my two grandsons.  It was a huge hit!  Even the baby loved it!  It was easy and didn’t require any weird ingredients!  Putting this in my meal rotation for sure!  

  7. Delicious! One of our go-tos

  8. It was great! We’re on low carb and this is about to become a permanent in our meal rotations. We added chili flakes (depending person eating it,) and some ranch on the side since we like ranch on our pizza too. 

    • Hey Izzy, so fun hearing from you! Glad to hear you and Josh enjoyed the recipe; hope you are doing well!

  9. We loved this!

  10. Can you cook this in the crockpot?
    I’d like to take for a work potluck.

    • I wish I could say yes, but I can’t really imagine how this is going to work in a crockpot. Let me know how it works out if you do try it.

  11. Thank you for the recipe and the tip on reducing the sauce. When the moisture in the sauce simmers away, and the chicken is pounded thin and browned, it really does prevent the dish from being watery and soggy.

  12. This is a huge hit at my house!!!! Used turkey pepperoni with italian seasoning! Delicious!

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  14. This will surely satisfy my appetite! Thanks for sharing this low carb pepperoni pizza chicken bake recipe!

  15. This looks so good! I can’t wait to try this on the weekend. Thanks a lot for sharing this recipe!

  16. When you cut the breast in half do you mean sideways or right down middle, I’m guessing sideways so it would be thinner but thought I’d ask to make sure

    • I pounded the chicken, so I cut it down the middle to make two smaller pieces, but I think your idea of cutting into two thinner slices is a good one too! Either way will work; you want pieces that are quite thin.

    • Could you use chicken thighs instead?

      • It may work with boneless, skinless chicken thighs, but I think they will need a lot more trimming to give a good result. I haven’t tried it that way.

      • Ive done it with thighs. It’s delicious! I actually only had thr oven at 350 ffor 30 min and then I broiled for 2 minutes to crisp and brown the cheese.

      • Allison, thanks for sharing that!

  17. Looking for easy keto bread recipe.

    • I recommend Google. I don’t have a recipe like that.

    • Try the 90 second microwave bread recipe

      1 egg
      1 T milk
      1 T coconut flour
      1 T almond flour
      1/4 t baking powder
      Combine ingredients…add to a coffee mug or small round cereal bowl (for hamburger buns) microwave 90 seconds. Slice and toast

      • Thanks for sharing Shirley. However that comment is from 2019, so sadly she will probably not see it.