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Slow Cooker (or oven) Low-Carb Mexican Lasagna Casserole

Use low-carb tortillas to make this delicious Slow Cooker Low-Carb Mexican Lasagna Casserole. Everyone who tried this tasty casserole loved the recipe and it’s also low-glycemic and South Beach Diet Phase Two! Use the Recipes-by-Diet-Type Index to find more recipes like this one.

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Slow Cooker Low-Carb Mexican Lasagna Casserole found on KalynsKitchen.com

Lately I’ve been infatuated with two things that inspired this Slow Cooker Low-Carb Mexican Lasagna Casserole: my Crock-Pot Casserole Crock Slow Cooker, and Mission Carb-Balance Low-Carb Tortillas. These two things also inspired the Low-Carb Slow Cooker Sour Cream Chicken Enchiladas I shared recently, and I’d have a hard time deciding whether I liked those enchiladas or this Mexican lasagna the best for a Mexican dinner made in the slow cooker.

The slow cooker casseroles I’m featuring every week for Casserole Crock Saturdays are another reason this Mexican lasagna casserole idea popped into my head. (Check out the Recipes-by-Photo Index Page for Casseroles to see all the Slow Cooker Casseroles I’ve featured on my slow cooker site!) And a layered Mexican dish like this worked perfectly in the casserole crock, but if you don’t have that new slow cooker that’s shaped like a casserole dish you can most definitely make this in a large oval slow cooker. And I am adding an option to bake it in the oven too, after a reader reported she tried it that way and it worked great.

I made this Mexican lasagna casserole when my brother Rand was staying at my house, and he ate the leftovers for days and raved about how good it was, and Kara reported it was also a hit with her family when she tried the casserole out on them. If you’re not into the idea of making casseroles in the slow cooker I think this could also be baked in the oven in a regular casserole dish, although I haven’t tried it that way. If anyone does try baking it, I’d love to hear in a comment about the cooking time and temperature you used.

(Just in case anyone is wondering, Crock-Pot and Mission Tortillas haven’t give me any free merchandise or payment to talk about their products, and they have no idea I am featuring them here.)

Slow Cooker Low-Carb Mexican Lasagna Casserole found on KalynsKitchen.com
Brown 2 pounds of lean ground beef; then add chopped onions and cook a few minutes more. Add Kalyn’s Taco Seasoning, salsa, and Ro-Tel tomatoes and simmer until the mixture is quite dry. While that cooks, mix together the cottage cheese, diced green chiles, eggs, and 1 cup of the grated cheese.

Slow Cooker Low-Carb Mexican Lasagna Casserole found on KalynsKitchen.com
Cut the low-carb tortillas in half so you have a straight edge to go along the sides of the slow cooker. Spray slow cooker insert with non-stick spray and make a layer of tortillas; then layer half the spicy beef mixture, half the cottage cheese, and 1 cup of the grated cheese. 

Slow Cooker Low-Carb Mexican Lasagna Casserole found on KalynsKitchen.com
Then make a second layer each of tortillas, spicy beef, cottage cheese mixture, and cheese. If you look hard you’ll see the casserole crock is a bit fuller in each of these photos!
Slow Cooker Low-Carb Mexican Lasagna Casserole found on KalynsKitchen.com
Cook on high for about 2.5 hours, or until it’s bubbling and the cheese is nicely melted. If you’re using the Crock-Pot Casserole Crock Slow Cooker you can brown the casserole a bit more in a 400F/200C oven for about 15 minutes, but that step is optional.

Slow Cooker Low-Carb Mexican Lasagna Casserole found on KalynsKitchen.com

And this is a quick photo I took as an afterthought, but you can see that the finished dish really does look like lasagna!

Slow Cooker Low-Carb Mexican Lasagna Casserole

(Makes 8-10 servings; recipe created by Kalyn and Kara and inspired by the Crock-Pot Casserole Crock Slow Cooker, and Mission Carb-Balance Low-Carb Tortillas.)

2-3 tsp. olive oil
2 lbs. lean ground beef
1 onion, chopped small
1 T Kalyn’s Taco Seasoning (or use your favorite purchased taco seasoning)
1 cup salsa (I used Pace Picante Sauce Medium)
2 cans (10 oz. can) Ro-Tel Tomatoes and Green Chiles (Use MILD if you’re making this for kids.)
about 6 low-carb tortillas, cut in half (I used Mission Carb-Balance Whole Wheat Low-Carb Tortillas with 4 carbs per tortilla)
2 cups cottage cheese (or use ricotta cheese if you prefer)
1 can (4 oz.) diced green chiles, drained
2 eggs
3 cups grated cheddar cheese, divided, or more if you like a lot of cheese. (I used Mexican Blend Cheese from Costco for this.)


Heat the oil in a large heavy frying pan, add the ground beef, breaking it apart with your fingers, and cook over medium-high heat until the beef is browned and cooked through. Break beef apart with a turner or old fashioned potato masher as it cooks so it’s in small pieces. When the beef is done, push it over to the side, add a little more oil if needed, and cook the diced onion for a few minutes; then mix the onion with the beef. Add the taco seasoning, salsa, and Ro-Tel tomatoes and simmer over low heat until most of the liquid has evaporated and when you draw a turner across the bottom of the pan you don’t see any liquid. 

While beef mixture cooks, mix together the cottage cheese, drained green chiles, eggs, and 1 cup of the cheese. Cut the tortillas in half with kitchen shears and spray the slow cooker insert with non-stick spray.

In the crockery casserole dish insert, make a layer of tortillas, using the cut side of the tortillas to go along the straight sides. Use the least amount of tortillas you can to cover the bottom. Make a layer of half the spicy meat mixture, half the cottage cheese mixture, and one cup of the grated cheese (or more). Then make a second layer each of the tortillas, meat mixture, cottage cheese mixture, and grated cheese.

Cover the slow cooker and cook on HIGH for about 2 1/2 hours or until the casserole is bubbling and the cheese is nicely melted. (I carefully lift the lid on the Crock-Pot Casserole Crock Slow Cooker at least once during the cooking time and pour off any accumulated liquid.) If you’re using the Casserole Crock, you can brown the finished dish in a 400F/200C oven for about 15 minutes if desired, but that step is completely optional. (Crock-Pot doesn’t recommend putting the casserole crock under the broiler.)


If you want to try this in the oven, a reader reported she baked it for 45 minutes and it turned out perfectly and was a hit with her husband. I’d use 375F/190C if you’re baking it in a casserole dish!

This will keep in the fridge for quite a few days and can be reheated in the microwave. I’m guessing it also freezes well, although I haven’t had any leftovers to freeze yet!

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Low-Carb Diet Low-Glycemic Diet / South Beach Diet Suggestions:

If made with low-carb tortillas, this dish would be suitable for phase 2 of the South Beach Diet, and probably would be suitable for many other low-carb eating plans for a maintenance phase.

Find More Recipes Like This One:

Use the Recipes by Diet Type photo index pages to find more recipes suitable for a specific eating plan. You might also like to Follow Kalyn’s Kitchen on Pinterest to see all the good recipes I’m sharing there.

Nutritional Information?

If you want nutritional information for a recipe, I recommend entering the recipe into Calorie Count, which will calculate it for you. Or if you’re a member of Yummly, you can use the Yum button on my site to save the recipe and see the nutritional information there.

More Casseroles in the Slow Cooker:
Photo Index Page for Casserole Recipes ~ Slow Cooker from Scratch

Slow Cooker Sausage and Four Cheese Lasagna ~ The Perfect Pantry

Slow Cooker Egg Casserole with Sausage, Peppers, Cottage Cheese, and Cheddar ~ Kalyn’s Kitchen

Slow Cooker Low-Carb Mexican Lasagna Casserole found on KalynsKitchen.com
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15 comments on “Slow Cooker (or oven) Low-Carb Mexican Lasagna Casserole”

  1. This was very good. My husband loved it. I baked it in my oven for 45 minutes instead of the slow cooker.

  2. Thanks for posting that, Jody! I was wondering about using the oven instead of the slow cooker!

  3. I want this to cook while I am at work, how long can I cook this in the crockpot on low?

    • I honestly have no idea how it would work to cook this all day on low, since I've never done it that way, but I kind of doubt that the flour tortillas will hold up to that long of a cooking time. But as I said, I really don't know. Maybe just try it; it will probably be edible, even if the tortillas get a bit mushy. Love to hear how it works if you do try it!

  4. Hi Kalyn, this sounds delish but my crockpot doesn't have an insert. Any ideas how it would turn it to put it straight in the crockpot? I'm guessing the biggest downside is going to be getting it out of the crockpot to store the leftovers! Not sure if the insert does something magical or if it changes the cooking time. thanks for all your great recipes and ideas!

    • Hi Marcia, glad you are enjoying the recipes. If you have a round, deep slow cooker, I'm not sure how that will work for this recipe. It's not that it's a separate part, but the crock is in the shape of a casserole for this model, so the layers are much thinner than they'll be in a smaller deeper slow cooker. And you're right, it will be hard to get it out. But let me know how it works if you try it, I am curious!

  5. if you want to store leftovers, put the entire crock pot in the fridge until cooled completely. Then portion out the servings. The fats will have solidified and the servings won’t fall apart when removing from the pot

  6. Pingback: 25 Low-Carb Slow Cooker Dinner Recipes Your Family Will Love

  7. Could you substitute the cottage cheese?

    • You could probably use ricotta if that’s what you’re thinking, but I haven’t tried it that way and I’m not sure how it will impact the wetness of the dish. (Getting too wet is the biggest issue with lasagna in the slow cooker.) If you’re cooking in the oven it probably won’t matter.

  8. I just found this recipe. I know this sounds weird, but do you think I could make this as just a casserole with out the tortillas? It sounds amazing!

    • I wonder about the amount of liquid, since some is absorbed into the tortillas. But yes, I think the taste would be good without tortillas. If you’re eliminating tortillas because of the carbs, you might look in Casseroles where there are a few recipes that are similar with lower-carb ingredients like cauliflower rice or whole green chiles layered with spicy beef.

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