Kalyn's Kitchen

Slow Cooker Mexican Lasagna Casserole

Make this Slow Cooker Mexican Lasagna Casserole in the Casserole CrockPot, a large oval slow cooker, or in a casserole dish in the oven. And if you use low-carb tortillas, this family friendly dinner idea is pretty low in net carbs!

PIN Slow Cooker Mexican Lasagna to try it later!

Slow Cooker (or oven) Low-Carb Mexican Lasagna Casserole close-up photo

Two things originally inspired this Slow Cooker Mexican Lasagna Casserole: the Crock-Pot Casserole Crock Slow Cooker that’s shaped like a casserole dish and My Favorite Low-Carb Tortillas. And slow cookers are definitely making a comeback during these times when we’re stuck at home cooking more often. But you can also bake this tasty Mexican Lasagna in the oven if the idea of using the slow cooker doesn’t appeal to you.

Using low-carb tortillas made this come out to 9.3 net carbs per serving, and it’s a family-friendly dinner that everyone in the house is probably going to like. What’s not to like about a tasty lasagna-inspired Mexican casserole with spicy ground beef, salsa, Ro-Tel tomatoes, low-carb tortillas, green chiles, cottage cheese, grated cheese, and just enough eggs to hold it together? And if you’re lucky you might have leftovers to freeze or to enjoy for another meal. Hope you’ll try this one for a tasty dinner option!

What Slow Cooker Did I Use?

A layered Mexican dish like this worked perfectly in the Crock-Pot Casserole Crock Slow Cooker (affiliate link), and I’m definitely a fan of that slow cooker for this kind of recipe. But if you don’t have the slow cooker that’s shaped like a casserole dish you can most definitely make this in a large oval slow cooker. And I’m adding an option to the recipe for baking it in the oven too, after a reader reported she tried it that way and it worked great.

What ingredients do you need for this recipe?

  • olive oil
  • ground beef
  • onion
  • Kalyn’s Taco Seasoning (or your favorite purchased taco seasoning)
  • Pace Picante Sauce (or your favorite low-sugar salsa)
  • Ro-Tel Tomatoes and Green Chiles
  • low-carb tortillas
  • cottage cheese
  • canned diced green chiles
  • eggs
  • grated Mexican Cheese Blend

Slow Cooker (or oven) Low-Carb Mexican Lasagna Casserole process shots collage

How to Make Slow Cooker Mexican Lasagna Casserole:

(Scroll down for complete printable recipe, including nutritional information.)

  1. Brown 2 pounds of lean ground beef; then add chopped onions and cook a few minutes more.
  2. Add Kalyn’s Taco Seasoning, salsa, and Ro-Tel tomatoes and simmer until the mixture is quite dry.
  3. While that cooks, mix together the cottage cheese, diced green chiles (affiliate link), eggs, and 1 cup of the grated cheese.
  4. Cut the low-carb tortillas in half so you have a straight edge to go along the sides of the slow cooker.
  5. Spray slow cooker insert with non-stick spray and make a layer of tortillas; then layer half the spicy beef mixture, half the cottage cheese, and 1 cup of the grated cheese.
  6. Then make a second layer each of tortillas, spicy beef, cottage cheese mixture, and cheese. If you look hard you’ll see the casserole crock is a bit fuller in the second photo!
  7. Cook on high for about 2.5 hours, or until it’s bubbling and the cheese is nicely melted. If you’re using the Crock-Pot Casserole Crock Slow Cooker (affiliate link) you can brown the casserole a bit more in a 400F/200C oven for about 15 minutes, but that step is optional.
  8. Serve hot, garnished with sliced green onions if desired.
  9. Scroll down to the complete recipe for instructions for baking this in the oven if you prefer that method.

Slow Cooker (or oven) Low-Carb Mexican Lasagna Casserole thumbnail photo

More Slow Cooker Casseroles:

Casserole Crock Pot Recipes ~ Slow Cooker or Pressure Cooker
Slow Cooker Sour Cream Chicken Enchiladas ~ Kalyn’s Kitchen
Slow Cooker Sausage and Four Cheese Lasagna ~ The Perfect Pantry
Slow Cooker Sausage and Egg Casserole ~ Kalyn’s Kitchen
Casserole Crock Slow Cooker Dinners ~ Slow Cooker or Pressure Cooker

Weekend Food Prep:

This recipe has been added to a category called Weekend Food Prep  to help you find recipes you can prep or cook on the weekend and eat during the week!

Slow Cooker (or oven) Low-Carb Mexican Lasagna Casserole close-up photo

Slow Cooker Mexican Lasagna Casserole

Yield 10 servings
Prep Time 20 minutes
Cook Time 2 hours 30 minutes
Total Time 2 hours 50 minutes

Use low-carb tortillas to make this delicious Slow Cooker Mexican Lasagna Casserole that can also be cooked in a casserole dish in the oven!


  • 1 T olive oil
  • 2 lbs. lean ground beef
  • 1 onion, chopped small
  • 1 T Kalyn’s Taco Seasoning (or use your favorite purchased taco seasoning)
  • 1 cup Pace Picante Sauce (see notes)
  • 2 cans (10 oz. can) Ro-Tel Tomatoes and Green Chiles (see notes)
  • 6 low-carb tortillas, cut in half (see notes)
  • 2 cups cottage cheese
  • 1 can (4 oz.) diced green chiles, drained
  • 2 eggs
  • 3 cups grated Mexican Cheese Blend (see notes)


  1. Heat the oil in a large heavy frying pan, add the ground beef, breaking it apart with your fingers, and cook over medium-high heat until the beef is browned and cooked through. Break beef apart with a turner or old fashioned potato masher (affiliate link) as it cooks so it’s in small pieces.
  2. When the beef is done, push it over to the side, add a little more oil if needed, and cook the diced onion for a few minutes; then mix the onion with the beef.
  3. Add Kalyn’s Taco Seasoning, salsa, and Ro-Tel tomatoes and simmer over low heat until most of the liquid has evaporated and when you draw a turner across the bottom of the pan you don’t see any liquid.
  4. While beef mixture cooks, mix together the cottage cheese, drained green chiles, eggs, and 1 cup of the cheese.
  5. Cut the tortillas in half with kitchen shears and spray the slow cooker insert with non-stick spray.
  6. In the crockery casserole dish insert, make a layer of tortillas, using the cut side of the tortillas to go along the straight sides. Use the least amount of tortillas you can to cover the bottom.
  7. Make a layer of half the spicy meat mixture, half the cottage cheese mixture, and one cup of the grated cheese (or more). Then make a second layer each of the tortillas, meat mixture, cottage cheese mixture, and grated cheese.
  8. Cover the slow cooker and cook on HIGH for about 2 1/2 hours or until the casserole is bubbling and the cheese is nicely melted. (I carefully lift the lid on the Crock-Pot Casserole Crock Slow Cooker at least once during the cooking time and pour off any accumulated liquid.)
  9. If you’re using the Casserole Crock, you can brown the finished dish in a 400F/200C oven for about 15 minutes if desired, but that step is completely optional. (Crock-Pot doesn’t recommend putting the casserole crock under the broiler.)

Oven Directions:

  1. If you want to try this in the oven, a reader reported she baked it for 45 minutes and it turned out perfectly and was a hit with her husband. I’d use 375F/190C if you’re baking it in a casserole dish!


I used Kalyn’s Taco SeasoningPace Picante Sauce MediumRo-Tel Tomatoes and Green Chiles, and Mission Carb-Balance Whole Wheat Low-Carb Tortillas for this recipe. (affiliate links) Use MILD Ro-Tel tomatoes if you're making this for kids. I used Mexican Blend Cheese from Costco. This will keep in the fridge for quite a few days and can be reheated in the microwave. I’m guessing it also freezes well, although I haven’t had any leftovers to freeze yet!

Recipe created by Kalyn and Kara and inspired by the Crock-Pot Casserole Crock Slow Cooker, and Mission Carb-Balance Low-Carb Tortillas.

Nutrition Information:



Serving Size:


Amount Per Serving: Calories: 593Total Fat: 26.8gSaturated Fat: 11.6gUnsaturated Fat: 10.9gCholesterol: 157mgSodium: 823mgCarbohydrates: 20.3gFiber: 11gSugar: 6gProtein: 41.6g

Nutrition information is automatically calculated by the Recipe Plug-In I am using. I am not a nutritionist and cannot guarantee 100% accuracy, since many variables affect those calculations.

If you make this recipe I'd love to hear how it turns out. Leave a star rating or share on social media with the hashtag #KALYNSKITCHEN, thanks!

Low-Carb Diet Low-Glycemic Diet / South Beach Diet Suggestions:
If you use the low-carb tortillas I recommend or a similar product, this recipe has 20.3 carbs but 11 grams of fiber in a serving. (That’s based on 10 servings; some people might want a larger serving so adjust accordingly.) If made with whole-grain tortillas, lean beef, and low-fat cheese, this dish would be suitable for phase 2 of the original South Beach Diet.

Find More Recipes Like This One:
Use Casserole Recipes to find more recipes like this one. Use the Recipes by Diet Type photo index pages to find more recipes suitable for a specific eating plan. You might also like to Follow Kalyn’s Kitchen on Pinterest to see all the good recipes I’m sharing there. Click here for more Slow Cooker / Pressure Cooker Recipes on my other site!

Pinterest image of Slow Cooker Mexican Lasagna Casserole

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    23 Comments on “Slow Cooker Mexican Lasagna Casserole”

  1. I made this for my family, we started low carb recently. I put in 6 tablespoons of taco seasoning, we like spice. I also made this in my slow cooker on low for 5 hours. Turned out great. Thank you, the leftovers won’t last long.

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  4. Made this tonight it was great ! My family just started low carb and it was a big hit ! 
    I also substituted black beans for meat and made a vegetarian one for myself . Both in the oven for 40 mins at 375 

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  7. I just found this recipe. I know this sounds weird, but do you think I could make this as just a casserole with out the tortillas? It sounds amazing!

    • I wonder about the amount of liquid, since some is absorbed into the tortillas. But yes, I think the taste would be good without tortillas. If you’re eliminating tortillas because of the carbs, you might look in Casseroles where there are a few recipes that are similar with lower-carb ingredients like cauliflower rice or whole green chiles layered with spicy beef.

  8. Could you substitute the cottage cheese?

    • You could probably use ricotta if that’s what you’re thinking, but I haven’t tried it that way and I’m not sure how it will impact the wetness of the dish. (Getting too wet is the biggest issue with lasagna in the slow cooker.) If you’re cooking in the oven it probably won’t matter.

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  10. if you want to store leftovers, put the entire crock pot in the fridge until cooled completely. Then portion out the servings. The fats will have solidified and the servings won’t fall apart when removing from the pot

  11. Hi Kalyn, this sounds delish but my crockpot doesn't have an insert. Any ideas how it would turn it to put it straight in the crockpot? I'm guessing the biggest downside is going to be getting it out of the crockpot to store the leftovers! Not sure if the insert does something magical or if it changes the cooking time. thanks for all your great recipes and ideas!

    • Hi Marcia, glad you are enjoying the recipes. If you have a round, deep slow cooker, I'm not sure how that will work for this recipe. It's not that it's a separate part, but the crock is in the shape of a casserole for this model, so the layers are much thinner than they'll be in a smaller deeper slow cooker. And you're right, it will be hard to get it out. But let me know how it works if you try it, I am curious!

  12. I want this to cook while I am at work, how long can I cook this in the crockpot on low?

    • I honestly have no idea how it would work to cook this all day on low, since I've never done it that way, but I kind of doubt that the flour tortillas will hold up to that long of a cooking time. But as I said, I really don't know. Maybe just try it; it will probably be edible, even if the tortillas get a bit mushy. Love to hear how it works if you do try it!

  13. Thanks for posting that, Jody! I was wondering about using the oven instead of the slow cooker!

  14. This was very good. My husband loved it. I baked it in my oven for 45 minutes instead of the slow cooker.