Horseradish Meatloaf is perfect to make on the weekend and enjoy during the week, and I’ve updated the recipe to be low in carbs!

PIN the Horseradish Meatloaf recipe to try it later!

Horseradish Meatloaf with Sour Cream-Horseradish Sauce finished meatloaf with sauce on plate

I think Horseradish Meatloaf with Sour Cream-Horseradish Sauce is really something special in the meatloaf world, with added flavor from caramelized onions, garlic, horseradish, Worcestershire sauce, and a touch of sour cream mixed into the meat before it’s cooked, and a tasty sauce of sour cream, mayo, and horseradish. And if you use my newly-preferred Flaxseed Meal to find the meatloaf together, this tasty meatloaf is low-carb and gluten-free!

But this is not quick and easy meatloaf. This is meatloaf to make on Sunday afternoon when you have time to gently caramelize the onions, mix the ingredients together, mix the sauce, and then enjoy leftover meatloaf for lunch all week. And if you’re a horseradish fan like I am, I hope you’ll think it’s worth the extra work for a meatloaf recipe that is so, so delicious!

What ingredients do you need for this recipe?

How did I make Horseradish Meatloaf lower in carbs?

I originally made this tasty meatloaf with a small amount of breadcrumbs, so it wasn’t gluten-free and did have a few carbs. But through the years I’ve started to love Flaxseed Meal (affiliate link) as a binder in meatloaf and meatballs, and the flax seeds have so much fiber that the net carbs are really low. I’ve switched out my recipe to be low-carb, but you can take your choice on using flaxseed meal for lower-carb and gluten-free meatloaf, or make the original version with the same amount of breadcrumbs if you prefer.

Want an Easier Meatloaf Recipe?

If you’re not up for this much work for meatloaf, you may want to make what my sister Pam dubbed Kalyn’s Best Meatloaf, a version I made for years with canned mushroom soup and onion soup mix. That was good meatloaf too, back in the day when I used to cook with those kinds of ingredients, but if you have more time, my dad gave the Horseradish Meatloaf two thumbs up!

Horseradish Meatloaf with Sour Cream-Horseradish Sauce process shots collage

How to make Horseradish Meatloaf:

(Scroll down for complete recipe with nutritional information.)

  1. Dice two medium onions into fairly small pieces, then heat olive oil and start to cook the onions. Let onions cook at low heat stirring every few minutes until onions are nicely browned and caramelized, about 30 minutes.
  2. Don’t rush the browning step and be sure onions don’t burn or they will be bitter.
  3. After onions cook for 15 minutes, start preheating oven to 375F/190C.
  4. Add minced garlic and dried thyme to the onions and cook about 2 minutes more.
  5. Mix together eggs, sour cream, Prepared Horseradish (affiliate link), and Worcestershire sauce.
  6. Put ground beef into a bowl and let it come to room temperature. When onions are done, add Flaxseed Meal (affiliate link) and onion-garlic mixture to the meat and season with salt and fresh ground black pepper. 
  7. Add egg/sour cream/horseradish/Worcestershire sauce mixture to meat. 
  8. Use your hands to gently combine until all the ingredients are well-mixed.
  9. I bought this broiler pan at a thrift store years ago, and love to use it to cook meatloaf. The slits let the fat drip down into the lower pan, so the meatloaf gets nice and crispy on the outside.
  10. Form the meat mixture into a loaf and place on top of the broiler pan (or roasting pan of your choice.) I like to make criss-cross slits on top of the meatloaf, but it’s completely optional!
  11. Bake meatloaf at 375F/190C for about 75 minutes, or until meat reaches 160F/55C on an  Instant Read Meat Thermometer (affiliate link). 
  12. Let meatloaf cool for 10-15 minutes before cutting; then serve with Sour Cream-Horseradish Sauce if desired.

Horseradish Meatloaf with Sour Cream-Horseradish Sauce thumbnail image of finished meatloaf

Make It a Low-Carb Meal:

Horseradish Meatloaf with Caramelized Onions and Sour Cream Horseradish Sauce would be great with Pureed Cauliflower with Garlic, Parmesan, and Goat Cheese or Twice Baked Cauliflower and Kale and Red Cabbage Slaw for a low-carb meal.

More Tasty Meatloaf or Meatballs:

Grain-Free Beef and Sausage Meatloaf
Meatloaf Balls with Italian Sausage, Ground Beef, and Peppers
Beef and Sausage Meatballs with Tomato Sauce

Horseradish Meatloaf with Sour Cream-Horseradish Sauce finished meatloaf with sauce on plate
Yield: 8 servings

Horseradish Meatloaf with Sour Cream-Horseradish Sauce

Prep Time 1 hour
Cook Time 1 hour 15 minutes
Total Time 2 hours 15 minutes

Make this Horseradish Meatloaf with Sour Cream-Horseradish Sauce on the weekend and enjoy leftovers during the week!

Ingredients

Ingredients

  • 2 medium onions, diced into small pieces
  • 1 T tsp. olive oil (more or less, depending on your pan)
  • 1 T finely minced garlic
  • 1 tsp. dried thyme
  • 2 eggs, beaten
  • 1/4 cup sour cream
  • 3 T cream-style horseradish (not horseradish sauce)
  • 1 T Worcestershire sauce
  • 2 lbs. ground beef
  • 1/2 cup Flaxseed Meal (see notes)
  • salt and fresh ground black pepper to taste

Sauce Ingredients

  • 1/4 cup sour cream
  • 2 T mayo
  • 2 T cream-style horseradish

Instructions

  1. Dice two medium onions into fairly small pieces, then heat olive oil in a large heavy pan and start to cook the onions over low heat.
  2. Let onions cook at low heat stirring every few minutes until onions are nicely browned and caramelized, about 30 minutes.
  3. Don’t rush this step and be sure onions don’t burn or they will be bitter.
  4. After onions cook for 15 minutes, start preheating oven to 375F/190C.
  5. Add minced garlic and dried thyme to the onions and cook about 2 minutes more.
  6. Mix together eggs, sour cream, horseradish, and Worcestershire sauce.
  7. Put ground beef into a bowl and let it come to room temperature.
  8. When onions are done, add Flaxseed Meal (affiliate link) and onion-garlic mixture to the meat and season with salt and fresh ground black pepper.
  9. Add egg/sour cream/horseradish/Worcestershire sauce mixture to meat. (Adding this on top of the onions will help cool them.)
  10. Use your hands to gently combine until all the ingredients are well-mixed.
  11. Form the meat mixture into a loaf and place on top of the broiler pan (or roasting pan of your choice.)
  12. I like to make criss-cross slits on top of the meatloaf, but it's completely optional!
  13. Bake meatloaf at 375F/190C for about 75 minutes, or until meat reaches 55-160F on an  Instant Read Meat Thermometer (affiliate link).
  14. Let meatloaf cool for 10-15 minutes before cutting; then serve with Sour Cream-Horseradish Sauce if desired.

Notes

I loved this with Flaxseed Meal (affiliate link) for a low-carb version, but make it with breadcrumbs if you prefer.

Recipe adapted by Kalyn from notes copied years ago from a friend’s cookbook, but unfortunately the notes didn’t include the name of the book.

Nutrition Information:

Yield:

8

Serving Size:

1

Amount Per Serving: Calories: 475Total Fat: 34gSaturated Fat: 12gTrans Fat: 1gUnsaturated Fat: 18gCholesterol: 168mgSodium: 252mgCarbohydrates: 6gFiber: 2gSugar: 2gProtein: 34g

Nutrition information is automatically calculated by the Recipe Plug-In I am using. I am not a nutritionist and cannot guarantee 100% accuracy, since many variables affect those calculations.

Did you make this recipe?

Did you make this recipe? Please leave a star rating (under the PRINT button in the recipe) or share a photo of your results on Instagram! THANKS!

Low-Carb Diet / Low-Glycemic Diet / South Beach Diet Suggestions:
When made with Flaxseed Meal (affiliate link), this Horseradish Meatloaf is a low-carb and low-glycemic recipe, suitable for low-carb eating plans. If it’s made with ground beef with 10% fat or less, the meatloaf is great for phase 2 or 3 of the original South Beach Diet. 

Find More Recipes Like This One:
Use Oven Dinners to find more recipes like this one. Use the Diet Type Index to find recipes suitable for a specific eating plan. You might also like to Follow Kalyn’s Kitchen on Pinterest to see all the good recipes I’m sharing there.

Historical Notes for this Recipe:
This recipe was posted in 2010. It was last updated with more information in 2021.

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